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Multiple Alignment Guides and Tutorial

Database Searching Tools

Multiple Alignment

Protein Families/Motifs/Domains

Protein Analysis Tools

Phylogeny

 

Guides and Tutorials to Biocomputing

Algorithms For Multiple Sequence Alignments

ClustalW: multiple sequence alignment.

EMBnet Biocomputing Tutorials

Guide to Sequence Analysis

*Introduction to making and using protein multiple alignments

Pasteur Institute: Guides, Tutorials and Documents

Primer on Molecular Genetics

Principles of Protein Structure


Database Searching Tools

BCM Search Launcher: General Protein Sequence/Pattern Searches.

Fasta3 Database Searches at the EBI.

MassSearch: Searching SwissProt or EMBL by protein mass after digestion.

**PROWL (protein searches) at Rockefeller - sequence and pattern searching


Multiple Alignment

AMAS: Analyse Multiply Aligned Sequences.

*BCM Search Launcher: Multiple Sequence Alignments.

Biology WorkBench - Alignment tools.

DCA: Divide-and-Conquer Multiple Sequence Alignment.

FHCRC: Block vs Block Searcher using LAMA.

FUNDP: Match-Box server.

**GeneBee: Multiple Sequence Alignment.

MSA : Multiple Sequence alignment using MSA version 2.1

*Multalin : Multiple sequence alignment by Florence Corpet.

*MultAlign: Multiple Sequence Alignment Tools.


Protein Families/Motifs/Domains

BLOCKS (Protein Motifs).

MOTIF: Searching Protein Sequence Motifs.

Pfam: Pfam is a high-quality comprehensive collection of protein domain families.

PRINTS: Protein Motif Fingerprint Database.

ProDom: The protein domain database

PROSITE is a method of determining what is the function of uncharacterized proteins translated from genomic or cDNA sequences.


Protein Analysis Tools

ProtParam tool (physical computation of proteins).


Phylogeny

Phylogenetic Software

MacClade : MacClade is a computer program for phylogenetic analysis.

PAML (Phylogenetic Analysis by Maximum Likelihood).

PHYLIP : PHYLIP is a free package of programs for inferring phylogenies.

TreeView : TreeView is a simple program for displaying phylogenies on Apple Macintosh and Windows PCs. Documentation for TreeView

 

Phylogeny Sites and Databases

Entrez Taxonomy Browser

Evolution and Phylogeny Laboratory: This laboratory provides various software packages for phylogenetic analysis as well as multiple sequence alignment.

Evolution Home Page : This is a site for various projects in evolution, molecular evolution and phylogenetic epidemiology.

IUBIO archive: This is a user-supported archive for biology software and data.

Phylogenetic Analysis Computer Programs

Phylogenetic tree prediction : Putative phylogenetic trees prediction for sequence multiple alignment by cluster and topological algorithms.

Phylogeny Programs

The Tree of Life : The Tree of Life is a project designed to contain information about the phylogenetic relationships and characteristics of organisms, to illustrate the diversity and unity of living organisms, and to link biological information available on the Internet in the form of a phylogenetic navigator.

TreeBASE: A Database of Phylogenetic Knowledge.

TreeGen : Tree generation from distance data.