Lab Headlines
![]() | HSF1
modulates oncogenesis by orchestrating a diverse network of cellular
functions. (a) With intact HSF1 function, cells accommodate the stressful
alterations imposed by either oncogene activation or tumor suppressor
inactivation by modulating diverse cellular responses, such as proliferation,
survival, signaling transduction, and metabolism. Ironically, the robustness
of a healthy cell is exploited by oncogenic stimuli to accomplish the
process of malignant transformation. (b) In contrast, with impaired
HSF1, cells are unable to adapt efficiently because of disarrayed cellular
responses. As a result, such cells demonstrate relative resistance to
malignant transformation (from Dai et al. 2007). |