| Reviews| 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 |
Shorter J, Lindquist S, 2008. Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions. EMBO J Oct 2. [Epub ahead of print] [PDF 2.1 MB]
Lo Bianco C, Shorter J, Régulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P, 2008. Hsp104 Antagonizes a-Synuclein Aggregation and Reduces Dopaminergic Degeneration in a Rat Model of Parkinson’s Disease. J Clin Invest, 118(9): 3087-97. [PDF 1.43 MB]
Chen D, Steele AD, Hutter G, Bruno J, Govindarajan A, Easlon E, Lin S-J, Aguzzi A, Lindquist S, Guarente L, 2008. The role of calorie restriction and SIRT1 in prion mediated neurodegeneration. Exp Gerontol, Aug 30. [Epub ahead of print]
Steele AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond G, Aguzzi A, Lindquist S, 2008. Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci USA, 105(36): 13626-13631. [PDF 1.7 MB]
Halfmann R, Lindquist S, 2008. Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis. J Visualized Experiments 17: 7/16/2008, doi: 10.3791/838. [JoVE video link]
Wang H, Duennwald ML, Roberts BE, Rozeboom LM, Zhang YL, Steele AD, Krishnan R, Su LJ, Griffin D, Mukhopadhyay S, Hennessy EJ, Weigele P, Blanchard BJ, King J, Deniz AA, Buchwald SL, Ingram VM, Lindquist S, Shorter J, 2008. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc Natl Acad Sci USA 105(20): 7159-64. [PDF 1.37 MB]
Douglas PM, Treusch S, Ren H-Y, Halfmann R, Duennwald ML, Lindquist S, Cyr DM, 2008. Chaperone-dependent amyloid assembly protects cells from prion toxicity. Proc Natl Acad Sci USA 105(20): 7206–11. [PDF 1 MB]
Johnson BS, McCaffery JM, Lindquist S, Gitler AD, 2008. A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proc Natl Acad Sci USA 105(17): 6439-44. [PDF 627 KB]
Fleming J, Outiero TF, Slack M, Lindquist SL, Bulawa CE, 2008. Detection of compounds that rescue rab1-synuclein toxicity. Methods Enzymol, 439: 339-51. [PDF 181 KB]
Sadlish H, Rampelt H, Shorter J, Wegrzyn RD, Andreasson C, Lindquist S, Bukau B, 2008. Hsp110 Chaperones Regulate Prion Formation and Propagation in S. cerevisiaeby Two Discrete Activities. PLoS ONE, 3(3): e1763. [PDF 737 KB]
Sangster TA, Salathia N, Undurraga S, Schellenberg K, Lindquist S, Queitsch C, 2008. HSP90 affects the expression of genetic variation and developmental stability in quantitative traits. Proc Natl Acad Sci USA, 105(8): 2963-68.[PDF 1.6 MB]
Sangster TA, Salathia N, Lee HN, Watanabe E, Schellenberg K, Morneau K, Wang H, Undurraga S, Queitsch C, Lindquist S, 2008. HSP90-buffered genetic variation is common in Arabidopsis thaliana. Proc Natl Acad Sci USA, 105(8): 2969-74. [PDF 1.0 MB]
Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S, 2008. The Parkinson’s Disease Protein Alpha-Synuclein Disrupts Cellular Rab Homeostasis. Proc Natl Acad Sci USA 105(1): 145-50. [PDF 832 KB]
Steele AD, Hetz C, Yi CH, Jackson WS, Borkowski AW, Yuan J, Wollmann RH, Lindquist S, 2007. Prion Pathogenesis is Independent of Caspase-12. Prion 1(4):1-5. [PDF 416KB]
Wendler P, Shorter J, Plisson C, Cashikar AG, Lindquist S, Saibil HR, 2007. Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104. Cell 131(7): 1366-77. [PDF 1.7 MB]
Hess S, Lindquist S, Scheibel T, 2007. Alternate assembly pathways of the amyloidogenic yeast prion determinant Sup35p-NM. EMBO Rep 8(12):1196-201. [PDF 332 KB]
Steele AD, King OD, Jackson WS, Hetz CA, Borkowski AW, Thielen P, Wollmann R, Lindquist S, 2007. Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. J Neurosci 27(47):13022-27. [PDF 320KB]
Dong J, Bloom JD, Goncharov V, Chattopadhyay M, Millhauser GL, Lynn DG, Scheibel T, Lindquist S, 2007. Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prions. J Biol Chem 282(47): 34204-12. [PDF 1.2MB]
Dai C, Whitesell L, Rogers AB, Lindquist S, 2007. Heat-shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell, 130: 1005-18. [PDF 1.2M]
Sangster TA, Bahrami A, Wilczek A, Watanabe E, Schellenberg K, McLellan C, Kelley A, Kong SW, Queitsch C, Lindquist S, 2007. Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels. PLoS ONE 2: e648. [PDF 812KB]
Alberti S, Gitler AD, Lindquist S, 2007. A suite of Gateway™ vectors for high-throughput genetic analysis in Saccharomyces cerevisiae. Yeast 24(10): 913-19. [PDF 972 KB]
Tessier PM, Lindquist S, 2007. Prion recognition elements govern nucleation, strain specificity and species barriers. Nature 447(7144): 556-61. [PDF 388 KB], [Supplementary Information]
Mukhopadhyay S, Krishnan R, Lemke EA, Lindquist S, Deniz AA, 2007. A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures. Proc Natl Acad Sci USA104(8): 2649-54. [PDF 864 KB] [Supplementary Materials]
Doyle SM, Shorter J, Zolkiewski M, Hoskins JR, Lindquist S, Wickner S, 2007. Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein- remodeling activity. Nat Struct Mol Biol 14(2): 114-22. [PDF 480 KB]
Steele AD, Jackson WS, King
OD, Lindquist S, 2007. The power of automated high-resolution behavior
analysis revealed by its application to mouse models of Huntington's and
prion diseases. Proc Natl Acad Sci USA 104(6):
1983-88.
[PDF 1.9 MB] [Supplementary
Materials]
Cowen LE, Carpenter AE, Matangkasombut O, Fink GR, Lindquist
S, 2006. Genetic Architecture of Hsp90-Dependent Drug Resistance. Eukaryot
Cell 5(12): 2184-8.
[PDF
374 KB]
Shorter J, Lindquist S, 2006. Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. Mol Cell 23(3): 425-38. [PDF 1.2MB]
Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, LaBaer J, Rochet J-C, Bonini NM, Lindquist S, 2006. alpha-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson’s Models. Science 313(5785): 324-8. [PDFLink]
Duennwald ML, Jagadish S, Muchowski PJ, Lindquist S, 2006. Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proc Natl Acad Sci USA103(29): 11045-50. [PDF 1.29 MB]
Duennwald ML, Jagadish S, Giorgini F, Muchowski PJ, Lindquist S, 2006. A network of protein interactions determines polyglutamine toxicity. Proc Natl Acad Sci USA 103(29): 11051-56. [PDF 1.46 MB]
Ehrnhoefer DE, Duennwald M, Markovic P, Engemann S, Roark M, Legleiter J, Muchowski P, Thompson LM, Lindquist S, Wanker EE, 2006. Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Human Molecular Genetics, 15(18):2743-51. [PDF 520KB]
Steele AD, Emsley JG, Özdinler PH, Lindquist S, Macklis JD, 2006. Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proc Natl Acad Sci USA 103(9): 3416-21. [PDF 1.39 MB]
Zhang CC, Steele AD, Lindquist S, Lodish HF, 2006. Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Proc Natl Acad Sci USA 103(7): 2184-9. [PDF 378 KB]
Homann OR, Cai H, Becker JM, Lindquist SL, 2005. Harnessing Natural Diversity to Probe Metabolic Pathways. PLoS Genet 1(6): e80. [PDF 1.2 MB]
Chen D, Steele AD, Lindquist S, Guarente L, 2005. Increase in activity during calorie restriction requires Sirt1. Science 310: 1641 (Brevia). [PDFLink]
Cowen LE, Lindquist S 2005. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 309: 2185-89. [PDFLink]
Krishnan R, Lindquist SL 2005. Structural insights into a yeast prion illuminate nucleation and strain diversity. Nature 435: 765-72. [PDF 468KB]
Cashikar AG, Duennwald M, Lindquist SL, 2005. A chaperone pathway in protein disaggregation: Hsp26 alters the nature of protein aggregates to facilitate reactivation by hsp104. J Biol Chem 280: 23869-75. [PDF 1.2MB]
Colby DW, Chu Y, Cassady J, Duennwald M, Zazulak H, Webster JM, Messer A, Lindquist S, Ingram V, Wittrup KD, 2004. Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single domain intrabody. Proc Natl Acad Sci USA 101:17616-21. Erratum in: Proc Natl Acad Sci USA 2005 102:955. [PDF 328KB]
Derkatch IL, Uptain SM, Outeiro TF, Krishnan R, Lindquist SL, Liebman SW, 2004. Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro. Proc Natl Acad Sci USA 101:12934-39. [PDF 532KB]
True H, Berlin I, Lindquist S, 2004. Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits. Nature 431: 184-87. [PDF 229 KB]
Shorter J, Lindquist S, 2004. Hsp104 Catalyzes Formation and Elimination of Self-Replicating Sup35 Prion Conformers. Science 304: 1793-97. [PDFLink]
Scheibel T, Bloom J, Lindquist SL, 2004. The Elongation of Yeast Prion Fibers Involves Separable Steps of Association and Conversion. Proc Natl Acad Sci USA 101: 2287-92. [PDF 333 KB]
Schirmer EC, Homann OR, Kowal AS, Lindquist S, 2004. Dominant Gain-of-Function Mutations in Hsp104p Reveal Crucial Roles for the Middle Region. Mol Biol Cell 15: 2061-72. [PDF 516KB]
Si K, Lindquist S, Kandel ER, 2003. A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties. Cell 115: 879-91. [PDF 636KB]
Outeiro TF, Lindquist S, 2003. Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology. Science 302: 1772-75. [PDFLink]
Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ, 2003. Yeast Genes that Enhance the Toxicity of a Mutant Huntingtin Fragment of alpha-synuclein. Science 302: 1769-72. [PDF 180KB]
Resende CG, Outeiro TF, Sands L, Lindquist S, Tuite MF, 2003. Prion protein gene polymorphisms in Saccharomyces cerevisiae. Mol Microbiol 49(4): 1005-17. [PDF 212KB]
Scheibel T, Parthasarathy R, Sawicki G, Lin X-M, Jaeger H, Lindquist SL, 2003. Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition.Proc Natl Acad Sci USA 100: 4527-32. [PDF 372 KB]
Liu J-J, Sondheimer N, Lindquist S, 2002. Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+]. Proc Natl Acad Sci USA 99: 16446-53. [PDF 376 KB]
Ma J, Lindquist S, 2002. Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol. Science 298: 1779. [PDFLink]
Ma J, Wollmann R, Lindquist S, 2002. Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. Science 298:1781-85. [PDFLink]
Queitsch C, Sangster TA, Lindquist S, 2002. Hsp90 as a capacitor of phenotypic variation. Nature 417: 618-24. [PDF 554 KB]
Cashikar AG, Schirmer EC, Hattendorf DA, Glover JR, Ramakrishnan MS, Ware DM, Lindquist S, 2002. Defining a pathway of communication from the C-terminal substrate binding domain to the N-terminal ATPase domain in a AAA protein. Mol Cell 9: 751-60. [PDF 424KB]
Hattendorf DA, Lindquist S, 2002. Analysis of the AA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with asite-specific fluorescent probe of nucleotide binding. Proc Natl Acad Sci USA 99: 2732-37. [PDF 344 KB]
Hattendorf DA, Lindquist S, 2002. Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants. EMBO J 21: 12-21. [PDF 280]
Scheibel T, Lindquist S, 2001. The role of conformational flexibility in prion propagation and maintenance for Sup 35p. Nat Struct Biol 8: 958-62. [PDF 136KB]
Ma J, Lindquist S, 2001. Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation. Proc Natl Acad Sci USA98: 14955-60. [PDF 584 KB]
Jensen MA, True HL, Chernoff YO, Lindquist S, 2001. Molecular population genetics and evolution of a prion-like protein in Saccharomyces cerevisiae. Genetics 159: 525-27. [PDF 144KB]
Uptain S, Sawicki G, Caughey B, Lindquist S, 2001. Strains of [Psi+] are distinguished by their efficiencies of prion-mediated conformational conversion. EMBO J 20: 1-10. [PDF 368KB]
Sondheimer N, Lopez N, Craig EA, Lindquist S, 2001. The role of Sis1 in the maintenance of the [RNQ+] prion. EMBO J 20: 2435-42. [PDF 224KB]
Scheibel T, Kowal AS, Bloom JD, Lindquist SL, 2001. Bi-directional amyloid fiber growth for a yeast prion determinant. Curr Biol 11: 366-69. [PDF 228 KB]
Schirmer EC, Ware DM, Queitsch C, Kowal AS, Lindquist S, 2001. Subunit interactions influence the biochemical and biological properties of Hsp104. Proc Natl Acad Sci USA 98: 914-19. [PDF 236 KB]
True HL, Lindquist SL, 2000. A yeast prion provides an exploratory mechanism for genetic variation and phenotypic diversity. Nature 407: 477-83. [PDF 324 KB]
Serio TR, Cashikar AG, Kowal AS, Sawicki GJ, Moslehi JJ, Serpell L, Arnsdorf MF, Lindquist S, 2000. Nucleated Conformational Conversion and the Replication of Conformational Information by a Prion Determinant. Science 289: 1317-21. [PDFLink]
Satyal SH, Schmidt E, Kitagawa K, Sondheimer N, Lindquist S, Kramer JM, Morimoto RI, 2000. Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans Proc Natl Acad Sci USA 97: 5750-55. [PDF 400KB]
Queitsch C, Hong S-W, Vierling E, Lindquist S, 2000. Hsp101 plays a crucial role in thermotolerance in Arabidopsis. The Plant Cell 12: 479-92. [PDF 656KB]
Krobitsch S, Lindquist S, 2000. Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc Natl Acad Sci USA 97: 1589-94. [PDF 493 KB]
Sondheimer N, Lindquist S, 2000. Rnq1, an epigenetic modifier of protein function in yeast. Mol Cell 5: 1-20.[PDF 348KB]
Li L, Lindquist S, 2000. Creating a protein-based element of inheritance. Science 287: 661-64. [PDFLink]
Rutherford SL, Lindquist S, 1998. Hsp90 as a capacitor for morphological evolution. Nature 396: 336-42. [PDF 552 KB]
Glover JR, Kowal AS,
Schirmer EC, Patino MM, Liu, J-J, Lindquist S, 1997. Self-seeded
fibers formed by Sup35, the protein determinant of
[PSI+], a heritable prion-like factor of Saccharomyces cerevisiae. Cell 89:
811-19. [PDF
272 KB]
Patino MM, Liu J-J, Glover JR, Lindquist S, 1996. Support for
the prion hypothesis for inheritance of a phenotypic trait in yeast. Science 273:
622-26.
[PDF1.88
MB]
Xu Y, Lindquist S, 1993. Heat-shock protein hsp90 governs the activity of pp60v-src kinase. Proc Natl Acad Sci USA 90: 7074-78. [PDF 2.8 MB]
Lindquist S, 1981. Regulation of protein synthesis during heat shock. Nature 293: 311-14. [PDF 852 KB]
McKenzie SL, Henikoff S and Meselson M, 1975. Localization of RNA from heat-induced polysomes at puff sites in Drosophila melanogaster. Proc Natl Acad Sci USA 72: 1117-11. [PDF 2.5 MB]
Steele AD, Lindquist S, Aguzzi A, 2007. The Prion Protein Knockout Mouse, A Phenotype Under Challenge. Prion 1(2): 83-93. [PDF 414 KB]
Whitesell L, Lindquist SL, 2005. Hsp90 and the Chaperoning of Cancer. Nat Rev Cancer 5(10): 761-72.[PDF 444 KB]
Shorter J, Lindquist SL, 2005. Prions as adaptive conduits of memory and inheritance. Nat Rev Genet. 6: 435-50.[PDF 824KB]
Sangster TA, Lindquist S, Queitsch C, 2004. Under Cover: causes, effects and implications of Hsp90-mediated genetic capacitance. Bioessays 26: 348-62.
Rochet JC, Outeiro TF, Conway KA, Ding TT, Volles MJ, Lashuel HA, Bieganski RM, Lindquist SL, Lansbury PT, 2004. Interactions Among alpha-Synuclein, Dopamine, and Biomembranes: Some Clues for Understanding Neurodegeneration in Parkinson’s Disease. J Mol Neurosci 23(1-2): 23-24. [PDF 220KB]
Lindquist SL, Henikoff S, 2002. Self-perpetuating structural states in biology, disease, and genetics. Proc Natl Acad Sci USA 99: 16377. [PDF 32KB]
Uptain SM, Lindquist S, 2002. Prions as Protein-Based Genetic Elements. Ann Rev Microbiol 56: 703-41. [PDF 536KB]
Serio TR, Lindquist SL, 2000. Protein-only inheritance in yeast: something to get [PSI+]-ched about. Trends Cell Biol 10: 98-105. [PDF 648KB]
Singer MA, Lindquist S, 1998. Thermotolerance in Saccharomyces cerevisiae: The yin and yang of trehalose. Trends Biotech 16: 460-68. [PDF 648KB]
Lindquist S, 1997. Mad cows meet psi-chotic yeast: The expansion of the prion hypothesis. Cell 89: 495-98. [PDF 48KB]
Tuite M, Lindquist S, 1996. The maintenance and inheritance of yeast prions. Trends Genet 12: 467-71. [PDF 392KB]
Schirmer EC, Glover JR, Singer, MA, Lindquist S, 1996. HSP100/Clp proteins: A common mechanism explains diverse functions. Trends Biochem Sci 21: 289-96. [PDF 912KB]
Parsell D, Lindquist S, 1993. The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins. Ann Rev Genet 27: 437-96. [PDF 3.5MB]
Lindquist S, 1992. Heat-shock proteins and stress tolerance in microorganisms. Curr Opin Gen & Dev 2: 748-55.
Yost HJ, Petersen RB, Lindquist S, 1990. RNA metabolism: strategies for regulation in the heat shock response. Trends Genet 6: 223-27.
Lindquist S, Craig E, 1988. The Heat-shock proteins. Ann Rev Genet 22: 263-77. [PDF 5.8 MB]
Lindquist SL, 1986. The heat shock response. Ann Rev Biochem 55: 1151-91. [PDF 5.1 MB]