Recent Publications

Hartl T, Boswell C, Orr-Weaver TL, Bosco G.
Developmentally regulated histone modifications in Drosophila follicle cells: initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation. Chromosoma. 2007 Apr; 116(2):197-214.

 

Vardy L, Orr-Weaver TL.
The Drosophila PNG kinase complex regulates the translation of cyclin B. Dev Cell. 2007 Jan;12(1):157-66.

 

Tadros W, Goldman AL, Babak T, Menzies F, Vardy L, Orr-Weaver T, Hughes TR, Westwood JT, Smibert CA, Lipshitz HD.
SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by PAN GU kinase. Dev Cell. 2007 Jan;12(1):143-55.

 

Resnick TD, Satinover DL, MacIsaac F, Stuckenberg PT, Earnshaw WC, Orr-Weaver TL, Carmena M.
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Dev Cell. 2006 Jul;11(1):57-68.

 

Ivanovska I, Khandan T, Ito T, Orr-Weaver TL.
A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes. Genes Dev. 2005 Nov 1;19(21):2571-82.

 

Lee LA, Lee E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW, Orr-Weaver TL.
Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Dev Cell. 2005 Mar;8(3):435-42.

 

Clarke AS, Tang TT, Ooi DL, Orr-Weaver TL.
POLO kinase regulates the Drosophila centromere cohesion protein MEI-S332. Dev Cell. 2005 Jan;8(1):53-64.

 

Dej KJ, Ahn C, Orr-Weaver TL.
Mutations in the Drosophila condensin subunit dCAP-G: defining the role of condensin for chromosome condensation in mitosis and gene expression in interphase. Genetics. 2004 Oct;168(2):895-906.

 

Lee JY, Dej KJ, Lopez JM, Orr-Weaver TL.
Control of centromere localization of the MEI-S332 cohesion protection protein.
Curr Biol. 2004 Jul 27;14(14):1277-83.

 

Claycomb JM, Benasutti M, Bosco G, Fenger DD, Orr-Weaver TL.
Gene amplification as a developmental strategy: isolation of two developmental amplicons in Drosophila. Dev Cell. 2004 Jan;6(1):145-55.

 

Ivanovska I, Lee E, Kwan KM, Fenger DD, Orr-Weaver TL.
The Drosophila MOS ortholog is not essential for meiosis. Curr Biol. 2004 Jan 6;14(1):75-80.

 

Lee LA, Van Hoewyk D, Orr-Weaver TL.
The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions. Genes Dev. 2003 Dec 1;17(23):2979-91.

 

Recent Reviews

Ivanovska I, Orr-Weaver TL.
Histone modifications and the chromatin scaffold for meiotic chromosome architecture. Cell Cycle. 2006 Sep;5(18):2064-71.

 

Clarke A, Orr-Weaver TL.
Sister chromatid cohesion at the centromere: confrontation between kinases and phosphatases? Dev Cell. 2006 May;10(5):544-7.

 

Wallace JA, Orr-Weaver TL.
Replication of heterochromatin: insights into mechanisms of epigenetic inheritance.
Chromosoma. 2005 Dec;114(6):389-402.

 

Claycomb JM, Orr-Weaver TL.
Developmental gene amplification: insights into DNA replication and gene expression.
Trends Genet. 2005 Mar;21(3):149-62.

 

Lee LA, Orr-Weaver TL.
Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues.
Annu Rev Genet. 2003;37:545-78.