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Publications
(most with links to downloadable PDFs)
2008
Sancak, Y., Peterson, T.R., Shaul, Y.D., Lindquist, R.A., Thoreen, C.C., Bar-Peled, L., and Sabatini, D.M. (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (Medline
Link) (Science reprint service) (PDF)
Reiling, J.H. and Sabatini, D.M. (2008) Increased mTORC1 Signaling UPRegulates Stress. Molecular Cell 29: 533-535. (Medline
Link) (PDF)
2007
Guertin, D.A. and Sabatini, D.M. (2007) Defining the role of mTOR in cancer. Cancer Cell 12: 9-22. (Medline
Link) (PDF)
Sancak,
Y., Thoreen,
C.C., Peterson, T.R., Lindquist,
R.A., Kang, S.A., Spooner, E., Carr, S.A., and Sabatini,
D.M. (2007) PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1
Protein Kinase. Molecular Cell 25: 903-915. (Medline
Link)
(PDF)
(Supp. Data)
Moffat, J., Reling, J.H., Sabatini,
D.M. (2007)
Off-target effects associated with long dsRNAs in Drosophila RNAi
screens. Trends Pharmacol Sci. (Medline
Link)
Lamprecht,
M.R., Sabatini,
D.M., Carpenter,
A.E. (2007)
CellProfiler: free, versatile software for automated biological
image analysis. Biotechniques 42:71-75.
(Medline Link)
2006
Zeng, Z., Sarbassov, D.D., Samudio, I.J., Yee, K.W., Munsell,
M.F., Jackson, C.E., Giles, F.J., Sabatini, D.M., Andreeff, M.,
Konopleva, M. (2006) Rapamycin derivatives reduce mTORC2 signaling
and inhibit AKT activation in AML. Blood (Medline
Link)
Guertin,
D.A., Stevens, D.M., Thoreen, C.C., Burds, A.A., Kalaany, N.Y.,
Moffat, J., Brown, M., Fitzgerald, K.J., Sabatini, D.M. (2006) Ablation
in Mice of the mTORC Components raptor, rictor,
or mLST8 Reveals that mTORC2 Is Required for Signaling
to Akt-FOXO and PKCalpha, but Not S6K1. Developmental Cell
11:859-871. (Medline
Link)
(PDF)
(Supp. Data)
Carpenter, A.E., Jones, T.R., Lamprecht, M.R., Clarke, C., Kang,
I.H., Friman, O., Guertin, D.A., Chang, J.H., Lindquist, R.A., Moffat,
J., Golland, P., Sabatini, D.M. (2006) CellProfiler: image analysis
software for identifying and quantifying cell phenotypes. Genome
Biology 7:R100. (Medline
Link)
(PDF)
Reiling, J.H. and Sabatini, D.M. (2006) Stress and mTORture signaling.
Oncogene 25: 6373-6383. (Medline
Link)
(PDF)
Echeverri, C.J., Beachy, P.A., Baum, B., Boutros, M., Buchholz,
F., Chanda, S.K., Downward, J.,Ellenberg, J., Fraser, A.G., Hacohen,
N., Hahn, W.C., Jackson, A.L., Kiger, A., Linsley, P.S., Lum, L.,
Ma, Y., Mathey-Prevot, B., Root, D.E., Sabatini, D.M., Taipale,
J., Perrimon, N., Bernards, R. (2006) Minimizing
the risk of reporting false positives in large-scale RNAi screens.
Nature Methods 3: 777-779.
(Medline
Link)
(PDF)
Root, D.E., Hacohen, N., Hahn, W.C., Lander, E.S., Sabatini, D.M.
(2006)
Genome-scale loss-of-function screening with a lentiviral RNAi library.
Nature Methods 3: 715-719.
(Medline
Link)
(PDF)
Frias M.A., Thoreen C.C., Jaffe J.D., Schroder W., Sculley T., Carr
S.A., and Sabatini D.M. (2006) mSin1 Is Necessary for Akt/PKB Phosphorylation,
and Its Isoforms Define Three Distinct mTORC2s. Current
Biology.
(Medline
Link)
(PDF)
(Supp.
Data)
Sabatini
D.M. (2006) mTOR and cancer: insights into a complex
relationship. Nature Reviews Cancer 6:
729-734. (Medline
Link)
(PDF)
Guertin, D.A., Guntur K.V., Bell, G.W., Thoreen, C.C. and Sabatini,
D.M.(2006) Functional Genomics Identifies TOR-Regulated Genes
that Control Growth and Division. Current Biology
16: 958-970.
(Medline
Link)
(PDF)
(Supp.
Data) (MS
Excel file of expression data)
Sarbassov, D.D., Ali, S,M, Sengupta, S., Sheen, J.-H.,
Hsu, P.P., Bagley, A.F., Markhard, A.L. and Sabatini, D,M. (2006)
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB.
Molecular Cell 22: 159-168.
(Medline
Link)
(PDF)
(Supp. Data)
Moffat, J., Grueneberg, D.A., Yang, X., Kim, S.Y., Kloepfer,
A.M., Hinkle, G., Piqani, B., Eisenhaure, T.M., Luo, B., Grenier,
J.K., Carpenter, A.E., Foo, S.Y., Stewart, S.A., Stockwell, B.R.,
Hacohen, N., Hahn, W.C., Lander, E.S., Sabatini, D.M., and Root,
D.E. (2006)
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an
Arrayed Viral High-Content Screen. Cell 124: 1283-1298.
(Medline
Link) (PDF)
(Supp. Data)
Guertin, D.A and Sabatini, D.M. (2006) Cell Size Control. In: Encylopedia
of Life Sciences. John Wiley & Sons, Ltd: Chichester
[doi:10.1038/npg.els.0003359]
(PDF)
Moffat, J. and Sabatini, D.M. (2006) Building mammalian signalling
pathways with RNAi screens. Nature Reviews Molecular Cell
Biology 7: 177-187. (Medline
Link) (PDF)
Bailey,
S.N., Ali, S,M, Carpenter, A.E., Higgins, C.O., Sabatini, D,M.(2006)
Microarrays of lentiviruses for gene function screens in immortalized
and primary cells. Nature Methods, 3: 117-122.
(Medline
Link) (PDF)
2005
Sarbassov, D.D., Ali, S,M, Sabatini, D,M. (2005) Growing roles for
the mTOR pathway. Current Opinion in Cell Biology
17: 596-603. (Medline
Link) (PDF)
Sarbassov,
D.D. and Sabatini, D.M. (2005) Redox regulation of the nutrient-sensitive
Raptor-mTOR pathway complex. J. Biol. Chem 280:39505-39509.
(Medline
Link) (PDF)
Guertin, D.A and Sabatini, D.M. (2005) An expanding role for mTOR
in cancer. Trends in Molecular Medicine 37: S25-S30.
(Medline
Link) (PDF)
Wheeler,
D.B, Carpenter, A.E., and Sabatini, D.M. (2005) Cell microarrays
and RNA interference chip away at gene function. Nature
Genetics Supplement 37: S25-S30. (Medline
Link) (PDF)
Ali, S.M. and Sabatini, D.M. (2005) Structure of S6K1 determines
if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif
site. J. Biol. Chem. 280:19445-8. (Medline
Link) (PDF)
Sarbassov, D.D., Guertin, D.A., Ali, S.M., and Sabatini, D.M. (2005)
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR complex.
Science 307:1098-1101. (Medline
Link) (PDF)
(Supp. Data)
2004
Bailey S.N., Sabatini D.M., Stockwell B.R. (2004) Microarrays of
small molecules embedded in biodegradable polymers for use in mammalian
cell-based screens. PNAS 101:16144-16149.
(Medline
Link) (PDF)
Wheeler, D.B., Bailey, S.N., Guertin, D.A., Carpenter, A.E., Higgins,
C.O., Sabatini, D.M. (2004) RNAi living-cell microarrays for loss-of-function
screens in Drosophila melanogaster cells. Nature Methods
1:127-132. (Medline
Link) (PDF)
(PDF of News&Views
article referring to this work) (Drosophila
RNAi cell microarray home page)
Sarbassov,
D., Ali, S.M., Kim, D.-H., Guertin, D.A., Latek, R.R., Erdjument-Bromage,
H., Tempst, P., Sabatini, D.M. (2004) Rictor, a novel binding partner
of mTOR, defines a rapamycin-insensitive and raptor-independent
pathway that regulates the cytoskeleton. Current Biology 14: 1296-1302. (Medline
Link) (PDF)
(Supp.
Data) (siRNAs
used).
Guertin, D. A., Kim, D.-H., and Sabatini, D. M. (2004) “Growth
Control Through the mTOR Network” in Cell Growth: Control
of Cell Size (Edited by Michael N. Hall, Martin Raff, and George
Thomas). pp193-234. Cold Spring Harbor Laboratory Press.
Thoreen, C.C. and Sabatini, D.M. (2004) Huntingtin aggregates ask
to be eaten. Nature Genetics 36: 553-554. (Medline
Link)
Carpenter, A.E. and Sabatini, D.M. (2004) Systematic Genome-Wide
Screens of Gene Function. Nature Reviews Genetics 5:
11-22. (Medline
Link) (PDF)
2003
Schalm,
S.S., Fingar, D.C., Sabatini, D.M., and Blenis J. (2003) TOS Motif-Mediated
Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function.
Current Biology 13: 797-806. (Medline
Link)
Kim,
D.-H., Sarbassov, D., Ali, S.M., Latek, R.R., Erdjument-Bromage,
H., Tempst, P., and Sabatini, D.M. (2003) GbL: a positive regulator
of the rapamycin-sensitive pathway required for the nutrient-sensitive
interaction between mTOR and raptor. Molecular Cell
11: 895-904. (Medline
Link) (PDF)
(siRNAs used)
Stewart,
S.A., Dykxhoorn, D.M., Palliser, D., Mizuno, H., Yu, E.Y., An, D.S.,
Sabatini, D.M., Chen, I.S.Y., Hahn, W.C., Sharp, P.A., Weinberg,
R.A., and Novina, C.D. (2003) Lentivirus-delivered stable gene silencing
by RNAi in primary cells. RNA 9: 493-501.(Medline
Link) (PDF)
2002
Kim, D.-H., and Sabatini, D.M. (2002) Raptor and mTOR: subunits
of a nutrient-sensitive complex. Current Topics in Microbiology
and Immunology. 279: 259-270. (Medline
Link)
Wu,
R., Bailey, S. and Sabatini, D.M. (2002) Cell biological applications
of transfected cell microarrays. Trends in Cell Biology,
12: 485-488. (Medline
Link) (PDF)
Kim,
D.-H., Sarbassov, D., Ali, S.M., King, J.E., Latek, R.R., Erdjument-Bromage,
H., Tempst, P., and Sabatini, D.M. (2002) mTOR interacts with raptor
to form a nutrient-sensitive complex that signals to the growth
machinery. Cell 110: 163-175. (Medline
Link)
(PDF)
(Supplemental
Data) (siRNAs
used)
Bailey,
S., Wu, R. and Sabatini, D.M. (2002) Applications of transfected
cell microarrays to drug discovery. Drug Discovery Today,
High-throughput Technologies Supplement: S113-118. (Medline
Link) (PDF)
Peng,
T., Golub, T., and Sabatini, D.M. (2002) The immunosuppressant rapamycin
mimics a starvation-like signal distinct from amino acid or glucose
deprivation. Mol. Cell. Bio. 22: 5575-5584. (Medline
Link) (PDF)
(Rapachip
website)
Hahn,
W.C., Dessain, S.K., Brooks, M.W., King, J.E., Elenbass, B., Sabatini,
D.M., DeCaprio, J.A., and Weinberg, R.A. (2002) Enumeration of the
pathways required for tumorigenic transformation of human cells.
Mol. Cell. Bio. 22: 2111-2123. (Medline
Link) (PDF)
pre 2002
Hentges, K.E., Sirry, B., Gingras, A.C., Sarbassov, D., Sonenberg,
N., Sabatini, D.M., Peterson, A.S. (2001). FRAP/mTOR is required
for proliferation and patterning during embryonic development in
the mouse. Proc. Natl. Acad. Sci. USA 98: 13796-13801.
(Medline
Link) (PDF)
Ziauddin,
J. and Sabatini, D.M. (2001) Microarrays of cells expressing defined
cDNAs. Nature 411, 107-110. (Medline
Link) (PDF)
(Reverse
Transfection Homepage)
Kumar, V., Sabatini, D., Pandey, P., Gingras, A.C., Majumder, P.K.,
Kumar, M., Yuan, Z.M., Carmichael, G., Weichselbaum, R., Sonenberg,
N., Kufe, D., Kharbandam S. (2000) Regulation of the rapamycin and
FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation
of translation by the c-Abl protein-tyrosine kinase. J.
Biol. Chem. 275:10779-87. (Medline
Link) (PDF)
Kumar, V, Pandey, P, Sabatini, D.M., Kumar, M, Majumder, P.K., Bharti,
A., Carmichael, G., Kufe, D., Kharbanda, S. (2000) Functional interaction
between RAFT1/FRAP/mTOR and protein kinase c d in the regulation
of cap-dependent initiation of translation. EMBO
19:1087-1097. (Medline
Link) (PDF)
Sabatini, D.M., Barrow, R.K., Blackshaw, S., Burnett, P.E., Lai,
M.L., Field, M.E., Bahr,B.A., Kirsch, J., Betz, H., Snyder, S.H.
(1999) Interaction of RAFT1 with the Clustering Protein Gephyrin
Required for Rapamycin-Sensitive Signaling. Science
284: 1161-1164. (Medline
Link) (PDF)
Walensky, L.D., Dawson, T.M., Steiner, J.P., Sabatini, D.M., Suarez,
J.D., Klinefelter, G.R., Snyder, S.H. (1998) The 12 kD FK 506 binding
protein FKBP12 is released in the male reproductive tract and stimulates
sperm motility. Mol. Med. 4: 502-514. (Medline
Link)
Burnett, P.E., Blackshaw, S., Mai, M.L., Qureshi, I.A., Burnett,
A.F., Sabatini, D.M. and Snyder, S.H. (1998) Neurabin is a synaptic
protein linking p70 S6 kinase and the neuronal cytoskeleton. Proc.
Natl. Acad. Sci. USA 95: 8351-8356. (Medline
Link) (PDF)
Snyder, S.H., Sabatini, D.M., Lai, M.M., Steiner, J.P., Hamilton,
G.S. and Suzdak, P.D. (1998) Neural actions of immunophilin ligands.
Trends Pharm. Sci. 19: 21-26. (Medline
Link)
Burnett, P.E., Barrow, R.K., Cohen, N.A., Snyder, S.H. and Sabatini,
D.M. (1998) RAFT1 phosphorylation of translational regulators p70
S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. USA
95: 1432-1437. (Medline
Link) (PDF)
Sabatini, D.M., Lai, M.M. and Snyder S.H. (1997) Neural roles of
the immunophilins. Molecular Neurobiology 15: 223-239.
(Medline
Link)
Khan, A.A., Soloski, M.J., Sharp, A.H., Schilling, G., Sabatini,
D.M., Li, S.H., Ross, C.A., and Snyder, S.H. (1996). Lymphocyte
Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Triphosphate
Receptor. Science 273: 503-507. (Medline
Link)
Sabatini, D.M., Pierchala, B.A., Barrow, R.K., Schell, M.J., and
Snyder, S.H. (1995). The Rapamycin and FKBP12 Target (RAFT) Displays
Phosphatidylinositol 4-Kinase Activity. J. Biol. Chem.
270: 20875-20878. (Medline
Link) (PDF)
Snyder, S.H. and Sabatini, D.M. (1995). Immunophilins and the nervous
system. Nature Medicine 1: 32-37. (Medline
link)
Cameron, A.M., Steiner, J.P., Sabatini, D.M., Kaplin, A.I., Walensky,
L.D. and Snyder, S.H. (1995). Immunophilin FK506 binding protein
associated with inositol 1,4,5-triphosphate receptor modulates calcium
influx. Proc. Natl. Acad. Sci. USA 92: 1784-1788.
(Medline
Link)
Erdjument-Bromage, H., Lui, M., Sabatini D.M., Snyder S.H. and Tempst,
P. (1994). High-sensitivity sequencing of large proteins: partial
structure of the rapamycin-FKBP12 target. Protein Science
3: 2435-2446. (Medline
Link)
Sabatini, D.M., Erdjument-Bromage, H., Lui, M., Tempst, P. and Snyder
S.H. (1994). RAFT1: A Mammalian Protein That Binds to FKBP12 in
a Rapamycin-Dependent Fashion and is Homologous to Yeast TORs. Cell
78: 35-43. (Medline
Link)
Baccarini, M., Sabatini, D.M., App, H., Rapp, U.R. and Stanley,
E.R. (1990). Colony Stimulating factor-1 (CSF-1) stimulates temperature
dependent phosphorylation and activation of the RAF-1 proto-oncogene
product. EMBO 9: 3649-3657. (Medline
Link)
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