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Lentiviral shRNA Collection Small interfering RNAs (siRNAs) expressed from short hairpin RNAs are proving to be a powerful way to mediate gene specific RNA interfering (RNAi) in mammalian cells. We are part of a consortium of labs at the Whitehead Institute, Broad Institute, Harvard Medical School, Dana-Farber Cancer Institute, Massachusetts General Hospital, and MIT Department of Biology that is collaborating to produce a pan-genomic collection of virally-expressed shRNAs that target human mRNAs. We anticipate using this collection in both traditional high-throughput well-based assays as well as to construct high-density loss of function cell microarrays.
More information on the viral shRNA library consortium
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