Enzymes that covalently modify histones
Protein
Organism
Comment
Acetylation
p55
T. thermophila
Gcn5-like
p80
T. thermophila
Preferentially acetylates H4
S. cerevisiae
B-type HAT, acetylates H4, believed to function in cytoplasm
S. cerevisiae
Transcriptional coactivator
S. cerevisiae
Gcn5-like, similar to yeast Hpa3
S. cerevisiae
MYST family, essential for viability
S. cerevisiae
MYST family, highly similar to yeast Sas2
S. cerevisiae
Associates with elongating RNA polymerase II
S. cerevisiae
Subunit of yeast TFIID
HatA
Z. mays
Two forms, A1 and A2 identified
HatB
Z. mays
B-type HAT
dTAFII230
D. melanogaster
Subunit of Drosophila TFIID
xHat1
X. laevis
Acetylates free H4
hTAFII250
H. sapiens
Subunit of human TFIID
TFIIIC220
H. sapiens
Subunit of human TFIIIC
TFIIIC110
H. sapiens
Subunit of human TFIIIC
TFIIIC90
H. sapiens
Subunit of human TFIIIC
hHat1
H. sapiens
Acetylates free H4
hGcn5-L
H. sapiens
Gcn5-like, transcriptional coactivator
PCAF
H. sapiens
Gcn5-like, transcriptional coactivator
CBP/p300
H. sapiens
Transcriptional coactivator
SRC-1
H. sapiens
Nuclear receptor coactivator, family includes TIF2/GRIP1
ACTR
H. sapiens
SRC family, Isoforms include RAC3, TRAM1, AIB1, p/CIP
HBO1
H. sapiens
MYST family, binds origin recognition complex
MORF
H. sapiens
MYST family, similar to human MOZ and Drosophila MOF
Tip60
H. sapiens
MYST family, HIV-1-Tat interacting protein
Deacetylation
S. cerevisiae
Involved in repression
S. cerevisiae
Deletions affect acetylation level in vivo
S. cerevisiae
Forms homodimer that has intrinsic activity
S. cerevisiae
Involved in aging, NAD+ dependent
HD1A
Z. mays
zmRpd3
Z. mays
HD1B-1
HD2
Z. mays
Nucleolar phosphoprotein
dRpd3
D. melanogaster
Affects silencing and position effect variegation
dHDAC3
D. melanogaster
xRpd3
X. laevis
Associates with multiple complexes
mHda2
M. musculus
Contains two HDAC domains
mHDAC1
M. musculus
mHDAC2
M. musculus
mHDAC3
M. musculus
mHDAC5
M. musculus
Previously mHda1
HDAC1
H. sapiens
Recruited by many DNA-binding regulators w/HDAC2
HDAC2
H. sapiens
Recruited by many DNA-binding regulators w/HDAC1
HDAC3
H. sapiens
Can associate with HDAC4 and HDAC5
HDAC4
H. sapiens
Cellular localization may regulate activity
HDAC5
H. sapiens
Can bind N-CoR/SMRT corepressors
HDAC6
H. sapiens
Contains two HDAC domains
HDAC7
H. sapiens
Can interact with SMRT corepressor
HDAC8
H. sapiens
Tissue-specific expression differs from other HDACs
hSir2
H. sapiens
Involved in aging, NAD+ dependent
Phosphorylation
JIL-1
D. melanogaster
Associated with dosage compensation
Rsk-2
H. sapiens
Phosphorylates H3 Ser 10, implicated in Coffin-Lowry disease
MSK1
H. sapiens
Phosphorylates H3 Ser 10
Methylation
CARM1
H. sapiens
Arginine-specific, histone H3 methyltransferase activity